From a technical level you should use something lossless in this situation, but it really quickly becomes impractical. Actually lossless 1080p60 is going to be something like 500mbps, so if you’re playing for an hour I hope you have a spare 2tb drive laying around. The artifacts in really high bitrate compressed video are so minimal that they basically don’t matter. Often codecs do noise removal first thing so whatever minor artifacts still exist will get smeared over by that anyway.
Also when you are testing make sure there’s some movement in the video. AV1 especially has modes for presentations and things that basically make a PowerPoint, so sizes might be unrealistic if you’re just recording your desktop. I don’t think that gets enabled in handbrake but it’s been a while since I looked.
To be fair, people are generally coming around to it and it’s kind of on it’s way to being a cult classic now. People say this about everything but it was actually ahead of its time in terms of its visual style and the way it deals with the serious elements within the wild cartoon visuals.
Weirdly, I kind of think Marvel movies like Guardians might have been the thing that tipped the scales. The breakneck editing is still way ahead of anything I’ve seen since though.