Elden Ring. Although that’s only because I didn’t want to start a whole new character for the DLC. Does Nier Automata count? All the extra playthroughs are kind of just part of the complete experience of the story. Then there’s harder difficulties of roguelikes like StS.
Beyond that, I tend to not end up being that interested in a NG+ unless there’s something substantially different about it like new story beats or I can play a cool build.
Only have a beginner perspective, but in school I did really well in intro CS class that used Python. 2nd class was in Java and it almost broke me I was so confused.